Hypothyroidism is a common endocrine disorder resulting from deficiency of thyroid hormone more rarely, from their impaired activity at tissue level. Deficiency of hormone has a wide range of effects, because all metabolically active cells require thyroid hormone. The clinical features of hypothyroidism are dependent on factors like age, disease condition and the rate at which hypothyroidism develops. Methimazole is an anti-thyroid drug belongs to the class of thioamide class used for induction of hypothyroidism. Commiphora mukul is the plant that is native to India and has important therapeutic properties in ancient Indian ayurveda system. Wistar rats of either sex were divided into following four groups (n=6). Group 1: Normal control animals received 1% CMC, 20 mg/kg p.o. Group 2: Disease control animals received methimazole 20 mg/kg p.o. dissolved in 1% CMC, Group 3: Low dose animals received Commiphora mukul (LDCM) (100 mg/kg) + methimazole (20 mg/kg) p.o. Group 4: High dose animals received Commiphora mukul (HDCM) (400 mg/kg) + methimazole (20 mg/kg) p.o. All the animals were treated for a period of 30 days. Treatment with methimazole for 30 days continuously increased MDA, TSH, triglycerides, total cholesterol and decreasedT3 and T4 levels in blood. Treatment with low and high doses of Commiphora mukul have decreased MDA, TSH, triglycerides and total cholesterol, increased T3 and T4 levels restoring them to normal. Treatment with low and high doses of Commiphora mukul restored histo architecture of thyroid gland. These results suggest that, Commiphora mukul possesses protective effect in methimazole induced hypothyroidism. This effect may be attributed to its major chemical compositions like terpenoids, steroids, flavonoids, guggultetrols, lignans, sugars, amino acids and guggulsterones
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